InterFuse® Intensive Treatment LINES by SkinBetter Science: A Clinically Proven Alternative to Injections
Expression lines like crow’s feet, forehead creases, and smile lines are among the most common aesthetic concerns patients bring to medspas. While injectable treatments such as Botox and dermal fillers are highly effective, not every patient is ready—or willing—to pursue that route.
Enter SkinBetter Science’s InterFuse® Intensive Treatment LINES: a medical-grade topical product clinically shown to significantly reduce the appearance of fine lines and dynamic wrinkles. Backed by peer-reviewed studies, this formula leverages a patented delivery system to push powerful peptides and hyaluronic acid deeper into the skin—targeting wrinkles at the source.
What Makes InterFuse® LINES Different?
Unlike most over-the-counter wrinkle creams, InterFuse LINES uses an advanced transdermal delivery system that helps large, active molecules penetrate through the skin barrier more effectively. The goal: bring therapeutic ingredients like high-molecular-weight hyaluronic acid and targeted peptides exactly where they’re needed.
The two-step protocol used in clinical trials involved:
InterFuse® HA Serum (InF-HA) – a topical hyaluronic acid serum containing five molecular weights of HA, including injectable-grade molecules.
InterFuse® Intensive LINES Cream (InF-PEP) – a concentrated peptide treatment formulated to soften the look of dynamic lines and stimulate collagen production.
When used in tandem, these two products create a high-performance, non-invasive approach to facial rejuvenation.
Key Ingredients: Backed by Biochemistry
Hyaluronic Acid (HA) – Multi-Molecular Weights
Five different HA molecule sizes target various skin layers.
The high-molecular-weight HA (up to 2.2 million Daltons) provides deep hydration and visible plumping.
Smaller molecules penetrate more deeply to support moisture retention and firmness at the basal layers of the skin.
Messenger Peptides
These peptides signal fibroblasts to produce collagen types I and III, which are responsible for firmness and elasticity.
Support the skin’s extracellular matrix, helping reduce the appearance of static and dynamic lines.
Neuro-Calming Peptides
Help relax facial tension in the upper skin layers.
Offer a topical alternative for softening expression lines caused by repetitive movement.
Niacinamide (Vitamin B3)
Improves barrier function and brightens skin tone.
Helps soothe inflammation and protect against environmental stressors.
Vitamin C (Ascorbyl Glucoside)
A stable antioxidant form of vitamin C that supports collagen synthesis and evens skin tone.
Clinical Trial Results: Evidence-Based Improvement in 8 Weeks
A dermatologist-led, open-label clinical study evaluated the effects of this two-step system on subjects aged 30–65 with moderate facial photodamage. Participants used the HA serum followed by the peptide cream twice daily for 8 weeks.
Results:
Crow’s feet: 31% reduction
Forehead lines: 23% reduction
Nasolabial folds: 68% improvement
Skin roughness: 27% improvement
Hyperpigmentation (dyschromia): 15–20% reduction
Subjects also reported a significant improvement in skin hydration, elasticity, and overall tone, with excellent tolerability and no serious adverse reactions. Only mild, transient dryness was noted in a few cases.
Citation: Study data from SkinBetter Science clinical trial published in Journal of Drugs in Dermatology and supported by manufacturer-released white papers.
Who Is This Product Best For?
Clients with visible expression lines around the eyes, mouth, and forehead
Patients seeking a topical alternative to neurotoxins or fillers
Individuals with sensitive or injection-averse skin
Post-injection patients wanting to extend the longevity of their results
Anyone looking to delay early signs of aging with evidence-based skincare
Is It a “Botox in a Bottle”?
While no topical product can match the targeted muscular relaxation of an injectable neurotoxin, InterFuse Intensive Treatment LINES is one of the few medical-grade formulas with data showing measurable reductions in dynamic lines. When used consistently, it can soften expression patterns, smooth texture, and visibly rejuvenate the skin’s surface.
Final Thoughts
With the right combination of ingredient science and clinical performance, SkinBetter Science has created a topical wrinkle solution that stands out in a crowded market. The InterFuse® delivery system is more than just a marketing term—it’s a clinically tested mechanism that allows ingredients to function where they’re most effective.
For patients seeking injectable-quality results without needles, or looking to support and maintain the results of aesthetic treatments, InterFuse® Intensive Treatment LINES offers a compelling, evidence-based solution.
Now Available at Our Medspa
We’re proud to be an authorized provider of SkinBetter Science products. To learn more about how InterFuse® LINES fits into your anti-aging regimen—or to schedule a skincare consultation—contact us or visit our clinic today.
